Aiming to be the premier nightclub in the Midwest, Europe Night Club is all about the music. This club boasts of a state-of-the-art sound system, light system and outstanding customer service. Focusing on live EDM music, Europe has hosted acts such as Skrillex, The Crystal Method, Starkillers and Chuckie, among others. There is a strict dress code, so make sure you dress to impress.

BB's Jazz, Blues & Soups has live music with top local performers and dinner served until midnight every night of the week. The music performed here is generally jazz or blues, and the musicians are always excellent. Soup is only a fraction of the home-cooked and tasty menu. Try such dishes as the Cajun chicken club sandwich or the catfish dinner. It is located in a building with a colorful past, which only adds to the unique atmosphere at BB's.

Hosting jazz acts from all over the nation, Jazz at the Bistro is the only place in St. Louis that keeps it jazz-tastic. Every blue moon, there are poetry/spoken word showcases or musicians from various genres, but the majority of the acts that come through this hip nightclub stay true to the name. Located amidst the city lights of the historic Grand Center, the intimate, fun atmosphere makes falling in love inevitable, whether it's with the great food, the great sounds, or the one you're with. The Bistro is also an excellent spot to book private parties, with a capacity of 250 people indoors and up to 400 outdoors in the adjacent Strauss Park.

As rated by the St. Louis Post Dispatch, Off Broadway is known for being the area's best place to see live music. The schedule of bands appearing here is always full. This venue is a great place to unwind, let loose and have a great time, whether you are visiting the city or you are a local resident looking to spend a night out. The venue has a funky ambiance with a retro tone. The spacious dance floor is usually packed. The music ranges from folk to rock and draws quite a varied clientele. No one will feel out of place here.

CBGB is a weird place. During the day, its appearance from the street makes this underground club look like an abandoned building, especially since the name of the business is drawn on the front door with spray paint. It's one of those places that draws a familiar crowd; everyone knows everyone and newcomers are easily identified and introduced to the rest of the group. The atmosphere can be considered alternative, frequented by hipsters with funky outfits, hairdos and musical interests. The best times to stop by are Wednesday, Friday, and Saturday nights. Though the ambiance has a distinctly edgy tone, the live music acts that come through are quite diverse and anyone can have a great time at the venue.

A great 21-and-over spot for fresh entertainment and fun in St. Louis, The Gramophone features nationally and locally known artists and DJs. Audiences can enjoy all types of music on various nights: blues, rock, hip hop, folk, old school, country, etc. There is plentiful seating on most nights, but if the place gets packed, the dance floor is always open. There is an impressive collection of specialty cocktails, wines, and beers.

The Pageant, a concert venue featuring an eclectic mix of live music, has showcased artists such as Gomez, The Thrills and Lucinda Williams. This space is intimate, ensuring a unique concert experience shared between audience and performer. The open floor is perfect for grooving to the music but there is also a balcony with seats for guests that are looking to get a clearer view in a more relaxed setting.

Westport Plaza is a great place to hang out, meet friends, eat, drink, and hear great live music. Backstreet Jazz and Blues is one of the top spots in the city to hear premier jazz and blues bands and share music with others. Jam sessions and karaoke are held on certain nights of the week and all are welcome to participate. Cocktails and drink specials are available for those 21 and above, and admission is incredibly affordable. Entry is free if you're carrying a ticket from the Funny Bone, a neighboring comedy club. The atmosphere is fun, flirty, and casual, but always be prepared for the unexpected. Many a local celebrity has been made at this live music venue and the next happening blues trombonist could be sitting at the bar.