One of the most prominent art museums in the world - Uffizi Gallery, is located in the Uffizi Complex that dates back to 1581. Much of the collection was bestowed upon the state of Tuscany by the Medici family in the 1700s to ensure that the work of some of Italy's greatest artists would remain where it belonged for the benefit of its people. The gallery consists of 40 rooms showcasing the work of some of the world's most renowned Renaissance masters, including Leonardo da Vinci, Michelangelo, Raphael and Caravaggio and also includes Botticelli's Birth of Venus and Primavera. Works of distinguished Flemish, Dutch and German painters are also on display here. The corridors and ceilings are anointed with splendid frescoes and lined with 16th-century Roman sculptures. Originally built to house legislative and administrative offices, the Uffizi Complex is a work of art in itself, designed by the noted architect, Giorgio Vasari.

Also called the Loggia della Signoria, the Loggia was named the Loggia dei Lanzi when the Duke Alessandro de' Medici made it the camp of the Lanzichenecchi after the fall of the Florentine Republic. It was the Signoria which commissioned a great Loggia for public use in 1350. The job was started by Orcagna, but continued and finished by Benci di Cione and Francesco Talenti only in 1382. Made in Serena stone with acute pointed arches and bricks decorated by sculptures designed by Agnolo Gaddi, this taste for a clasical style is what characterises Florentine art of the time. Benvenuto Cellini's famous Perseus was installed under the Loggia, and in the central arch Giambologna's marble Rape of the Sabine Women, which can be found next to Hercules with Nessus also in marble. The other statues at the back near to the walls came from the Medici villa in Rome.

The building which contains the Museo Nazionale del Bargello dates back to 1255. In the 16th Century, it became the residence of the bargello (head of police) and doubled as a prison. Then halfway through the 19th Century it was given to the national museum. A visit begins with the splendid courtyard and the ground floor room where some of Michelangelo's masterpieces are exhibited, including the bust of Brutus and the David-Apollo statue. There are several of the early works of Donatello on the first floor, amongst them statues of David in marble and of St George and David in bronze. Also here are terracottas, glazed by Luca della Robbia, of the Virgin Mary with Child. The museum bought some minor decorative art including ivories from the Roman and the Byzantine periods, medieval enamels, German and French goldsmith's art and Renaissance jewelry.